CNS.4U – Human iPS Cell-Derived Central Nervous System Cells – in development

Fig. 1: Immunocytochemical staining of CNS.4U^TM cells (red: Astrocyte marker S100B; green: Neuronal marker Beta-3-tubulin; blue: Dapi)

Human physiological hiPSC-derived cell systems bear the major advantage of having an increased “test-system/target-system compatibility”.

The CNS.4U^TM cells are composed of two of the key cell types present in the human central nervous system (CNS), i.e. Astrocytes and Neurons. The latter may be subdivided into GABAergic, glutamatergic and dopaminergic neurons.

Parallel generation of neurons and astrocytes from the same human iPSC line recapitulates the inter-cellular interactions between both cell types and better mimics the inherent cellular mechanisms. CNS.4U^TM are suitable for drug screenings, for prediction of pharmacological responses in vitro as well as for disease modeling in a dish.