The detection of intracellular Ca++ transients in (recombinant) cell lines is widely used in high-throughput screening (HTS) of drug compounds due to high specificity, robustness, throughput and sensitivity. Since calcium ions are the major trigger for the initiation of contraction in cardiomyocytes, such set-up can also be used for HTS screening of compounds affecting cardiac contraction (e.g. beat rate, rhythmicity, beat duration) in early cardiac safety testing. Cor.4U® human iPS cell-derived cardiomyocytes combine a primary-like phenotype (e.g. regular beating pattern) with unlimited availability and constant quality, therefore being an ideal model to detect changes in calcium handling in HTS assays.
Unique features:
- High-throughput assay for cardiomyocyte function using primary-like, functional cardiomyocytes.
- Predictive for a variety of cardiac targets (cardiac PCRs, ion channels, transporters, etc.).
- Highly standardized cell model in combination with automatable screening technology