Cells Cor.At® ES derived Cardiomyocytes
Species Mouse
Cell Source     Mouse ES cells: Strain 129S2 SvPas
Cell Format     Monolayer of pure cardiomyocytes
Service content     Analysis of effects of test compounds on field action potentials and other electrophysiological properties of mouse ESC derived Cor.At cardiomyocytes
Delivery A study protocol will be sent to initiate the study.
Timeline Draft report: within 4 weeks
Quotation

Mel.Cor® is an in vitro assay that utilizes Axiogenesis Cor.At® cardiomyocytes to reproduce an authentic cardiac cellular environment for drug pharmacology screening. Mel.Cor® has important natural features that are lacking in current electrophysiological in vitro assay methods and is capable to display hERG effects.

Mel.Cor® is a physiologically authentic system that integrates a full range of cellular mechanisms which regulate cardiac potentials, such as the interaction between ion channel subunits (Na+, Ca2+, K+). Mel.Cor® also permits the simultaneous detection of drug effects on all ion channels, as well as on beta-adrenergic and muscarinic receptors. Other current systems for in vitro electrophysiological analysis do not provide this physiologically accurate cardiac cellular environment so the data they produce is of limited value. Mel.Cor® is also highly efficient and economical and thus can be particularly beneficial in screening large compound libraries.

Advantages Mel.Cor

  • Standardized, primary-like, and pure cardiomyocytes.
  • Assessment of the potential to delay cardiac repolarization.
  • Predictive for pharmcology preclinical safety pharmacology.
  • Non-invasive test system.
  • Low amount of compound required.
  • Cost effective.