Cells mES cells, MCF-7, and S. typhimurium
Species Mouse; human; bacterial
Reporter GFP/none.
Purity 100%
Service Content Investigation of acute toxicity, embryotoxicity, estrogenic activity, and mutagenicity of chemicals and consumer goods as material extracts prepared according DIN ISO 10993-12 and DIN EN 1186-1
Delivery A study protocol will be sent to initiate the study. Results are sent as draft and final study report.
Timelines Experiment time: 10 weeks per compound.
Draft report: within 12 weeks
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ToxEffect screening

The ToxEffect screening is a combination of 4 cell based in vitro assays which covers the most severe toxicity endpoints, namely cytotoxicity (XTT test), embryotoxicity (µEST test), mutagenicity/genotoxicity (SOS-umu test), and hormonal activity (E-Screen test). With the ToxEffect Screening, the test material (either a chemical or a consumer good material) will be checked for the release of hazardous substances in amounts which lead to toxic effects in our cell culture test battery. This test battery provides a high level of information, indicating which type of toxicity should be monitored further. 

Advantages ToxEffect Screening
  • Comprehensive collection of proven in vitro assays to cover the most severe toxicity endpoints.
  • Predictive, relevant and robust cell culture test battery capable of medium throughput screening.
  • Detection of the biological effect of a hazardous component is possible even if the toxic agent itself is unknown.
  • Testing of consumer goods possible due to robust and relevant extraction technique (according to DIN ISO 10993-12 and DIN EN 1186·1).
  • Early and quick results makes ToxEffect Screening suitable for supply chain verification.