Cells Cor.4U® Human iPS derived cardiomyocytes
Species Human.
Cell Source Induced pluripotent stem (iPS) cells (caucasian)
Cell Format Beating clusters of human CM.
Service Content

Electrophysiological analysis
Delivery

A study protocol will be sent to initiate the study.
Timeline

Draft report: within 4 weeks.
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Cor.4U® human cardiomyocyte-based Mel.Cor® MEA assay service

Human Cor.4U® Mel.Cor® is an in vitro and non-invasive assay system to monitor Axiogenesis' Cor.4U® human cardiomyocytes by means of extracellular field potential recordings from microelectrode arrays (MEA).

The Cor.4U® human cardiomyocytes reveal electrophysiological properties typical for human cardiac myocytes like functional Na+, Ca2+, and K+ voltage-gated ion channels including the hERG channel and their correct modulation through e.g. ß-adrenergic or muscarinic receptors. 

The combination of the Cor.4U® human cardiomycoytes with the Mel.Cor® MEA assay provides an idea tool to assess pharmacological, safety pharmacological and toxicological effects of drug candidates on human cardiomyocytes.

 

Human iPS-derived cardiomyocytes after actinin staining.

Advantages Cor.4U MEA
  • primary-like cardiomyocytes of human origin.
  • non-invasive test system.
  • predictive and relevant for cardiac safety pharmacology.
  • low amount of compound required.