Until today, manual Patch Clamp remains the "gold standard" of electrophysiological assay systems to accurately assess drug interactions with cardiac or neuronal ion currents I(Na), I(Ca), and I(K). With high quality recordings, the effect of pharmacological active compounds on membrane resting potential and action potential waveform can easily be evaluated.
Axiogenesis' human iPSC-derived cell lines provide a primary-like cardiomyocyte or neuronal phenotype, offering the opportunity to study multiple and complex interactions between test compounds and cellular functional proteins, like ion channels, ion exchangers and transporters.
- "Gold-standard" functional cardiomyocyte or neuron ion channel assay
- The phenotype of primary-like human cardiomyocytes and neurons in a highly standardized, convenient cell model
Accurate, high quality recordings of both cardiac ion currents and action potentials
Manual Patch Clamp Services are offered by Axiogenesis and their collaboration partners