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Manual patch clamp

Axiogenesis has developed Cor.At® cardiomyocytes to provide scientists in basic or applied cardiology and toxicology a standardized and pure cardiac myocyte model with functional expression of all three essential cardiac ion currents. 

Manual patch clamp recordings revealed that Cor.At® cardiomyocytes exhibit typical cardiac action potentials and the three essential cardiac currents INa, ICa, and IK (Fig. 1 and 2 below). 
These mouse embryonic stem cell-derived cardiomyocytes are ready-to-use and 100% pure without contamination by other cell types.
Cor.At® cardiomyocytes enable scientists to adequately address the efficacy and safety pharmacology of potential lead compounds in drug discovery and development.
Advantages Manual Patch Clamp with stem cell-derived cardiomyocytes
  • 'Gold standard' of electrophysiological assay systems.
  • Primary-like cardiomyocytes.
  • High quality recording of cardiac ion currents I(Na), I(Ca), I(K) and action potentials.